tert-Butyl N-[4-(aminomethyl)phenyl]carbamate

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate - Names and Identifiers

Name	tert-Butyl N-[4-(aminomethyl)phenyl]carbamate
Synonyms	4-(Aminomethy)-1-N-Boc-Aniline 4-(Aminomethyl)-1-N-Boc-aniline 4-(AMINOMETHYL)-1-N-BOC-ANILINE 2-(4-CHLOROPHENOXY)MALONDIALDEHYDE 4-(TERT-BUTOXYCARBONYLAMINO)BENZYLAMINE 4-(tert-Butoxycarbonylamino)benzylamine TERT-BUTYL 4-(AMINOMETHYL)PHENYL CARBAMATE tert-butyl [4-(aminomethyl)phenyl]carbamate TERT-BUTYL N-[4-(AMINOMETHYL)PHENYL]CARBAMATE tert-Butyl N-[4-(aminomethyl)phenyl]carbamate (4-AMINOMETHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER (4-AMINOMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS	220298-96-4
InChI	InChI=1/C12H18N2O2/c1-12(2,3)16-11(15)14-10-6-4-9(8-13)5-7-10/h4-7H,8,13H2,1-3H3,(H,14,15)

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate - Physico-chemical Properties

Molecular Formula	C12H18N2O2
Molar Mass	222.28
Density	1.120±0.06 g/cm3(Predicted)
Melting Point	64-68°C(lit.)
Boling Point	300.1±25.0 °C(Predicted)
Flash Point	135.3°C
Vapor Presure	0.00114mmHg at 25°C
pKa	13.68±0.70(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.564
MDL	MFCD02183573

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns R22 - Harmful if swallowed R43 - May cause sensitization by skin contact
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves.
WGK Germany	3
Hazard Class	IRRITANT

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate - Introduction

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate is an organic compound with the chemical formula C15H22N2O2. The following describes its nature, use, preparation and safety information.

Nature:
tert-Butyl N-[4-(aminomethyl)phenyl]carbamate is a solid, white crystalline powder at room temperature. It has low solubility and can be dissolved in organic solvents (such as chloroform, dimethylformamide). It is a stable compound with a long retention period when stored under dry conditions.

Use:
tert-Butyl N-[4-(aminomethyl)phenyl]carbamate is commonly used in some reactions and catalytic processes in organic synthesis. It can be used as a raw material or intermediate for the synthesis of biologically active compounds or drugs. It has certain application potential in the field of medicinal chemistry and pharmaceutical research.

Method:
The preparation method of tert-Butyl N-[4-(aminomethyl)phenyl]carbamate can be carried out by the following steps:
1. First, Aniline reacts with formaldehyde to generate aminomethyl compounds.
2. Next, the obtained aminomethyl compound is reacted with tert-butyl chloroformate to generate the tert-Butyl N-[4-(aminomethyl)phenyl]carbamate.

Safety Information:
tert-Butyl N-[4-(aminomethyl)phenyl]carbamate currently has no clear toxicity data reported, general laboratory safety practices should be followed. It may cause irritation to the eyes, skin and respiratory system. Wear appropriate protective equipment such as lab gloves and goggles during use. In case of accidental spilling or inhalation, rinse immediately with water and seek medical help.

Please note that the above information is for reference only. Please be familiar with the safety information and handling methods of the relevant compounds before operation, and operate in a suitable laboratory environment.

Last Update：2024-04-09 21:01:54